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Mission District Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Mission District Vacation Packages

Price found within the past 48 hours. Click for updated prices.
  • An outdoor seating area with wicker furniture, a glass-top fire pit, and potted plants.
    Jan 21 - Jan 25

    Hotel Riu Plaza Fisherman's Wharf + Flight

    Fisherman's Wharf
    4 nights
    4.0 star property
    9.0/10 - Wonderful (7,736 reviews)
    "They do NOT disclose the 14% Occupancy Tax until checkout. $200 extra dollars for TWO NIGHTS."
    Reviewed November 6, 2026
    Roundtrip • Edmonton (YEG) - San Francisco (SFO)
    YEG - SFO • 1 stop SFO - YEG • 1 stop
    CA $1,180
    CA $860
    per traveller
    found 15 hours ago
    Hotel Riu Plaza Fisherman's Wharf
  • A historic building with a prominent corner entrance, a tram line, and a flag.
    Jan 21 - Jan 25

    Stanford Court San Francisco + Flight

    Downtown San Francisco
    4 nights
    4.0 star property
    9.0/10 - Wonderful (1,857 reviews)
    "N/A"
    Reviewed November 6, 2026
    Roundtrip • Edmonton (YEG) - San Francisco (SFO)
    YEG - SFO • 1 stop SFO - YEG • 1 stop
    CA $1,549
    CA $1,034
    per traveller
    found 15 hours ago
    Stanford Court San Francisco
  • An aerial view of a resort with a large swimming pool surrounded by sun loungers and a vineyard.
    Dec 12 - Dec 18

    Montage Healdsburg + Flight

    Healdsburg
    6 nights
    5.0 star property
    9.6/10 - Exceptional (143 reviews)
    "Amazing!"
    Reviewed November 4, 2026
    Roundtrip • Toronto (YTO) - San Francisco (SFO)
    YYZ - SFO • 1 stop SFO - YYZ • 1 stop
    CA $4,815
    CA $3,322
    per traveller
    found 19 hours ago
    Montage Healdsburg
  • A modern hotel lobby with a reception desk, dining area with tables and chairs, and a decorative light fixture.
    Jan 10 - Jan 15

    Hotel 1550 - SFO Airport + Flight

    San Bruno
    5 nights
    3.5 star property
    8.8/10 - Excellent (1,017 reviews)
    "I stayed for only one night because I needed to be close to the airport for an early flight. I was wondering if I should have stayed at a hotel that was closer, but the shuttle service from and to the airport was efficient; I needn’t have worried. The room was spotlessly clean and comfortable - just what I needed."
    Reviewed November 5, 2026
    Roundtrip • Vancouver (YVR) - San Francisco (SFO)
    YVR - SFO • Nonstop SFO - YVR • Nonstop
    CA $2,505
    CA $1,791
    per traveller
    found 1 day ago
    Hotel 1550 - SFO Airport
  • A grand lobby with a chandelier, arched windows, and a 'CLUB WYNDHAM' doormat.
    Jan 26 - Jan 31

    Club Wyndham Canterbury + Flight

    Union Square
    5 nights
    3.0 star property
    9.2/10 - Wonderful (784 reviews)
    "Clean room, very friendly staff."
    Reviewed October 12, 2026
    Roundtrip • Toronto (YYZ) - San Francisco (SFO)
    YYZ - SFO • Nonstop SFO - YYZ • Nonstop
    CA $1,962
    CA $1,417
    per traveller
    found 10 hours ago
    Club Wyndham Canterbury

Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
Learn more about Mission District
A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.
A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.
A pier with a large number of sea lions resting on floating platforms.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.
A city street with tall buildings, flags, and cars.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.
A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Discover the most popular places to visit in Mission District

A park with people sitting on the grass, a school building, and a cityscape in the background.

Mission Dolores Park

9.4/10 (3 reviews)
Mission Dolores Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Discover the beautiful sunsets and top-notch restaurants in this vibrant area.
See properties

What to do near Mission District

California Academy of Sciences General Admission

California Academy of Sciences Daytime Admission

CA $69
per adult
86% of travellers recommend
California Academy of Sciences Daytime Admission
See all activities near Mission District

Mission District Hotel Deals

A wooden outdoor bar set with a variety of snacks, wine glasses, and bottles in a bucket.

Parker Guest House San Francisco

Parker Guest House San Francisco
3.5 star property
Mission District
9.6 out of 10, Exceptional, (513 reviews)
"I loved my stay at the Parker Guesthouse. It felt like visiting in a lovely home with a gracious host. The person at the front desk when I checked in was kind and professional and gave me a brief history about the houses. My room in the main house was spotless. The bed was very comfortable and furnished beautifully. The living room, kitchen, and guest dining rooms were elegant but my favorite area was the garden. It's a peaceful oasis in the city where in October, there were still flowers...
The price is CA $321
CA $374 total
includes taxes & fees
Nov 10 - Nov 11
Parker Guest House San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mission District

Frequently Asked Questions

How much does a Mission District vacation package cost?

Our Mission District packages, which begin at just CA $860, are an awesome way to save big. Pick your favorite flights, hotels and rental cars to create a customized escape.

How do I get a cheap travel package to Mission District?

By bundling. Flights, rental cars and hotels — combine whatever you need into a Mission District vacation package to save a pile of cash. Score even more deals when you add extras such as sightseeing tours to your booking. But that's not the only impressive part. You have the freedom to customize your vacation your own way. We offer more than 550 partner airlines and 1,000,000 hotels worldwide, so that everyone has a chance to travel and live out those vacation dreams.

Where should I stay in Mission District?

A visit to Mission District isn't complete until you've seen Pier 39 and Alcatraz Island. Book a room close by for quick access to these popular attractions.

What are the top hotels in Mission District?

If it's your first time staying in Mission District, lock in a room at 1906 Mission or Charming And Cozy Dolores Park Condo By Redawning. Both will make you feel at home and are favorites among lots of travelers.

How far in advance should I book my Mission District vacation?

To bag rock-bottom prices, book ASAP. Airlines usually start selling tickets, along with some of the lowest fares, around 12 months ahead of time. Hotels, car rental and experiences should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in Mission District, there are always lots of great deals to be had on Expedia. Book your escape today!

What does an Expedia Mission District travel package include?

It all boils down to what sort of getaway you want to have. Mission District vacation deals can include car rentals, hotels and flights. You can mix and match to create the travel package that fits your needs. You can also add on activities and experiences after you've booked to pick up even bigger discounts.

What should I know before booking a Mission District travel package?

Booking all the parts of your escape together is one of the best ways to save. Bundle your car rentals, airfares and hotels into a convenient package. But you're not restricted to hotels. Expedia has all types of properties, including vacation rentals like beachfront villas and serviced residences. You've got loads of choices!

Can I choose my airline with a Mission District Expedia vacation package?

With a vacation package, you're always in charge. Whether you want to fly to Mission District in first class or coach, simply select from the available airline options. Expedia has access to more than 550 airline partners around the world.

If I'm not able to travel, can I cancel my Mission District vacation package?

You sure can, and we're here to help. You may be able to cancel or change your Mission District vacation package for free if you booked in the last 24 hours. But you may incur a fee from your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans unexpectedly change, visit our Customer Service Portal for more information.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.